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A novel, multitargeted endogenous metabolic modulator composition impacts metabolism, inflammation, and fibrosis in nonalcoholic steatohepatitis-relevant primary human cell models

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These 15 altered metabolomics pathways resulted in increased levels of glutamate, 4-Aminobutanoate, carnosine, thymine, porphobilinogen, homogentisate and 4-Guanidinobutanoate in the R group ( Figure 5B , Supplementary Figure 4A )

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Gln is metabolized by GLS to produce alpha-ketoglutaric acid (-KG), which serves as a crucial cofactor for TET enzymes that catalyze DNA demethylation, as well as for histone demethylases like JHDM

An increase in the activity of matrix-metalloproteases (MMPs) or an increase in neuronal glucose uptake are two likely mechanisms by which inhibition of IRAP can provide an enhancement of memory